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The concentration of -glutamyl- S -allyl-L-cysteine in cells of these tissues is calculated to be approximately 38 M, when the content of water in tissues is estimated to be 90%

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True pathological hypercortisolism (Cushing's syndrome) is typically caused by endogenous ACTH excess, adrenal disease, or exogenous glucocorticoid medication use , rather than by chronic psychological stress alone