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Neuroimaging consisted of MRI acquisition before and after the intervention in all studies, except for the studies of Cukierman-Yaffe et al

Rarely, an allergic reaction could occur, manifesting as rashes, swelling, or difficulty breathing

In PIONEER 6, no significant differences were observed between the two groups for nonfatal stroke (HR 0.74 [95% CI 0.351.57]) or nonfatal MI (HR 1.18 [95% CI 0.731.90]) [16]

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However, Maiorino and co-workers recently redefined the catalytic motif of GPx1 as tetrad by establishing through mutagenesis study in Drosophila model that asparagine (Asn or N) residue was also essential for the catalytic activity of GPx1 [13]