Contraindications to be aware of You should not take Mounjaro if you have: A personal or family history of medullary thyroid carcinoma Multiple endocrine neoplasia syndrome type 2 (MEN 2) A history of severe allergic reaction to tirzepatide Severe gastroparesis (delayed stomach emptying) You should not take metformin if you have: Severe kidney impairment (eGFR below 30) Acute or chronic metabolic acidosis Diabetic ketoacidosis Who should consider this combination
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However, the effect of peptide polyagonists needs further exploration in animal studies as well as in mechanistic studies to investigate the potentially additive or synergistic effect of different receptor agonists, and their specific mechanisms of action
Tirzepatide (Mounjaro, Zepbound) keeps the GLP-1 activity and adds a second incretin receptor, GIP
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