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Glucose levels in blood after intestinal administration of semaglutide exceed those achieved after intravenous administration (Figure 6)

Further, it may impact pathways associated with sleep dysregulation in research models in laboratory trials

As a result, they are effective treatment options for people with T2D, achieving glycated haemoglobin reductions, weight loss and potential cardiovascular benefit, as monotherapy or as add-on to other glucose-lowering therapies

doi: 10.1038/s41531-018-0058-0 85 YangWHamiltonJLKopilCBeckJCTannerCMAlbinRLet al

The preclinical-to-clinical translation of this principle requires further validation, but the data are directionally consistent