In fact, for many patients, microdosing is more effectivebecause it allows them to stay on the medication longer , build foundational health habits, and avoid the yo-yo cycle of starting and stopping due to side effects
In the clinical experience of some authors of this Advisory, another approach is to maintain individuals at the lowest effective dose and escalate only as needed (i.e., when weight reduction ceases or efficacy wanes), although shortages of medications at lower doses may be a barrier
Notably, discontinuation is associated with weight regain and partial or complete reversal of improvements in cardiometabolic risk factors, including inflammatory markers, blood pressure, lipid profile, and blood glucose levels
Many report continuing the healthy habits they built while taking the drug
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