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DRP-104 has been tested in clinical trial NCT04471415 to assess the preliminary safety and efficacy in patients with advanced solid tumors as a single drug or combined with anti-PD-L1 immunotherapy (Atezolizumab)

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Several review articles [11,81,82] discuss the causal relationship between an impairment of the homeostasis of redox-active metal ion and the irreversible transformation of biological constituents, such as proteins, lipids and the DNA strand, into oxidation products, and of the following biochemical impairment to the onset of a wide array of diseases