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doi:10.1111/dom.13956 [DOI] [PubMed] [Google Scholar] 20.Halawi H, Khemani D, Eckert D, et al

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This matters because: Muscle is your primary metabolic engine each kilogram burns approximately 13 calories per day at rest If you lose significant muscle during your semaglutide program, your maintenance calorie needs drop making it much easier to regain weight after stopping Rebuilding muscle after losing it is significantly harder than preserving it in the first place People who lose mostly fat (not muscle) during their semaglutide program maintain weight loss far better after tapering off 7