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The positive correlations in human CSF of Xan and several monoamines including 5-HIAA have been noted earlier ( PURINERGIC SIGNALING, CLINICAL IMPROVEMENT, AND NEUROLOGICAL DEFICITS Associations between purine metabolites and clinical and neurological symptoms were examined before and after 4w antipsychotic treatment ( greater improvement in clinical functioning 1 month later ( Figure 4 )

GHK-Cu (glycyl-L-histidyl-L-lysine:copper(II)) is a naturally occurring copper-binding tripeptide first isolated from human plasma by Pickart and Thaler in 1973

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Physiol Behav 228:113187