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2.2 Experimental animals and design Male and female ICR-CD1 mice aged between 46 weeks and 2535 g, obtained from the Centre for Comparative Medicine Research (CCMR) of the University of Hong Kong, were used in the study

Taking all this data together it seems logical or appropriate to conclude that, because IGF1-R has a different signalling pathway that can maintain lipid oxidation in the liver, FFA uptake in muscle, and activates mTORC1 could reactivate IR through tyrosine kinase activity on IRS, thus displacing serine phosphorylation, reinstituting insulin signalling

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L., Gibbs, T