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Final weight)/Initial weight 100 The percentage moisture loss studies are done to determine physical stability and integrity of the film

Results Safety No clinically significant changes from baseline values of the hematology or clinical chemistry were observed at any of the time points sampled following ARA 290

Superoxide sensitivity of the Escherichia coli aconitase

Sensitivity analysis The results were insensitive to variations in the identification of cohort 2 (Table 5)

The animals fed a selenium-deficient diet recapitulated some of the pathological manifestations of KBD, strongly supporting the notion that selenium deficiency is critically associated with the development of this endemic arthropathy