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Many people who stop using weight loss drugs will return to their previous weight within two years, a new review of existing research has found

(Oral Wegovy was approved in December 2025, but requires fasting before and after each dose.) In clinical trials, patients on the highest dose lost approximately 27 lbs (12.4% body weight) over 72 weeks

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This contributes to central sensitization of pain pathways, promotes visceral afferent sensitization, and induces neurogenic inflammation