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Recent FDA Approvals and Advances in Anti-obesity Drugs Breakthrough Treatments: Semaglutide and Tirzepatide The long-acting glucagonlike peptide-1 ( GLP-1 ) receptor agonist S emaglutide (Wegovy

There are also pen-like injection devices that deliver medication with the click of a button (FDA, 2013)

This may contribute to the diarrhoea sometimes reported with GLP-1 receptor agonist treatment

These receptors are highly expressed in the area postrema, nucleus tractus solitarius, and hypothalamus, brain regions critical for appetite regulation and energy homeostasis

Furthermore, dihydroethidine (DHE) staining showed that the proportion of DHE-positive cells after OGD treatment was higher than that in the control group, suggesting that the level of reactive oxygen species (ROS) was increased (Figure 3G)