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In animal models, NOD2 and Atg16l1 mutant mice exhibit specific immune cell composition and cytokine profile changes in a natural microbiome environment, directly demonstrating that both genetics and the environment jointly regulate gut immunity [245]

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Safety concerns include common gastrointestinal side effects, such as nausea and vomiting, as well as potential risks related to the pancreas, gallbladder, and thyroid C-cell tumors