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- Chronic therapies (cardiac, diabetes, respiratory, CNS) are growing faster than acute therapies (antibiotics, anti-infectives, pain) and now dominate the portfolios of leading companies

Contraindications : GLP-1 receptor agonists are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

Liver disease : liver enzyme monitoring is recommended in community use, and a baseline ALT/AST check is reasonable before starting

We next analyzed whether SnCE1 has an acetyltransferase (AcT) activity although the -helix of the extended VR-3 in ChlaDUB1 is missing in SnCE1

Capone F, Nambiar N, Schiattarella GG