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When a single molecule is proposed to help the liver, the vasculature, the nervous system, and the aging process all at once, the breadth of the claim is itself a reason for caution, not enthusiasm: broad, database-derived promise is exactly the kind of signal that most often fails to survive controlled testing

Here's what can happen when we don't get enough folate: Severe congenital disabilities since folate demand is higher in pregnancy

Aside from cytosolic amino acid sensors, intra-lysosomal amino acid sensing coincided with the identification of SLC38A9, a lysosomal transmembrane protein likely belonging to arginine transporters and an integral part of mTORC1 activation via Ragulator-RAG GTPases (Jung et al., 2015

doi: 10.1016/j.hermed.2020.100404 84

Immunity 21 , 179188 (2004)