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This is one of the key drivers of mitochondrial failure, accumulation of irreparable DNA damage and cellular aging across tissues

Furthermore, Chek1/2 inhibition was shown to reverse radioresistance in CD133-positive glioma stem cells [65]

These cardiovascular benefits may relate to the peptide's stress-reducing effects, since chronic stress contributes to hypertension and cardiac dysfunction

This is in line with the findings of Nemet et al., (2020), who reported PAGln as a gut-derived, phenylalanine-based metabolite with pro-thrombotic effects via adrenergic receptor signaling (Nemet et al., 2020)

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