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The omega-3 fatty acids docosahexaenoic acid and eicosapentaenoic acid serve a role in reducing the resistance of tumor cells to bortezomib by activating the serine synthesis pathway, mitochondrial folate cycle, methionine cycle-associated GSH synthesis and ChaC1-mediated GSH degradation in tumor cells, ultimately promoting GSH degradation (138)

[DOI] [PubMed] [Google Scholar] 46.Fruehauf JP, Trapp V

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Four Regions of Interest (ROIs) were drawn using the 3D ROI Tool on 6 slices of each of the scans