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Understanding the mechanisms underlying METH-induced neurotoxicity is essential for developing effective treatment strategies to mitigate its devastating effects

[DOI] [PMC free article] [PubMed] [Google Scholar] Prescott L

In 2017, Neelakantan and colleagues first systematically characterized 5amino1mq during screening for selective NNMT inhibitors, with findings published in Biochemical Pharmacology - marking the official discovery and public reporting of the compound.Through structural modification of quinolinebased precursors, the team identified 5amino1mq as a small, membranepermeable molecule with the chemical formula CHN.With an extremely low IC value, it became one of the most promising selective NNMT inhibitors available at the time, with high specificity and no significant inhibition of other metabolically relevant enzymes

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Liang D, Minikes AM, Jiang X