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Our multilayer integration selected a subset of molecular components, suggesting mitochondrial and metabolic dysfunction are contributors to long-term symptoms following critical COVID-19

Management of ARIA may include discontinuation of the medication either temporarily or indefinitely To ensure that ARIA is identified should it occur, the appropriate use recommendations (AUR, i.e., guidelines for clinicians to administer new therapies safely and effectively) for lecanemab suggest health care professionals obtain MRI scans of the brain before the 5th, 7th, 14th and 26th infusions, in addition to a baseline scan before starting treatment

Because 4 units is such a small draw, use a U-100 syringe and confirm the mark before injecting

doi: 10.23736/S2724-5276.17.04910-6 76

Practical Guidance and Take-Aways There are a number of practical pointers that HCPs should consider when evaluating off-label risk