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The pivotal trial supporting its 2010 FDA approval enrolled 816 HIV-infected adults with clinically defined lipodystrophy, and Phase 3 data documented visceral fat reductions of roughly 15-18% over 26 weeks of treatment a result robust enough to clear FDA review for a defined medical indication

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Glia 63:365382 Carretero J, Obrador E, Pellicer JA, Pascual A, Estrela JM (2000) Mitochondrial glutathione depletion by glutamine in growing tumor cells

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One problem with GHK-Cu is that it is very sensitive to breakdown by carboxypeptidase enzymes