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269 The multilineage differentiation potential of aged HSCs is impaired, showing a bias toward myeloid differentiation (erythroid, granulocytic, and megakaryocytic lineages), whereas the differentiation ability toward lymphoid lineages (T cells, B cells) is significantly reduced

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These fatty acids are extremely susceptible to oxidative damage by free radicals or Reactive Oxygen Species (ROS) by a process called lipid peroxidation (LPO)

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