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However, its concentration drops significantly with age, by more than half after the age of 60 [2]

This means that oral delivery may also provide good peptide absorption through the stomach mucosa, following intragastric application

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Further, long-term use of acid-reducing drugs and the anti-diabetes drug metformin and repeated exposure to nitrous oxide have been implicated in vitamin B 12 deficiency (see Drug interactions)

13, Issues 1112, pp