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Previous literature has also identified rs10305420 as influencing GLP1 receptor agonist efficacy 25,26 , although with opposite directionality to our study

Such mutations impair cellular uptake of riboflavin, leading to reduced FMN and FAD synthesis and consequent dysfunction of mitochondrial FAD-dependent enzymes, culminating in axonal degeneration, motor neuron disease, and sensory neuropathy

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