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Each combination of amino acids produces unique and very specific functions

This has spurred an extensive interest in engineering of antibody formats with improved efficacy for both therapeutic and prophylactic use 3

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Oxidized PAC-quinone imine metabolites have also been shown to form GSH-conjugates which inhibit glutathione reductase (GR): the decreased activity of GR hampers the detoxification and antioxidant capacity of the GSH-GSSG cycle, further aggravating the pro-oxidative status in the cell (Ndlov et al., 2014)

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