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Similarly, ROS are produced by activated HSCs in response to ROS released from adjacent cells such as destroyed hepatocytes and activated Kupffer cells

p97 is a homo-hexamer, in which each subunit comprises two ATPase domains, D1 and D2, that assemble into two stacked rings (Fig

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The involvement of oxidative stress in PCC has been reported by multiple groups 22,23,26,59,60,61,62,63