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A healthy mucosal lining prevents pathogens and toxins from entering the bloodstream, reducing the risk of conditions like leaky gut syndrome

Pfeffer, C

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In vitro permeability model Cell models In vitro cell models include Caco-2, MDCK, and LLC-PK1, etc, among which Caco-2 cells are derived from human colon cancer cells and are widely used to study the bidirectional drug delivery and Caco-2 model is one of the most essential tools to elucidate the "druggability" of oral candidate compounds [13]