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PDRN inhibits melanogenesis through downregulation of microphthalmia-associated transcription factor (MITF), and the 2024 Tsai split-face RCT demonstrated significant melasma severity reduction with combined microneedling radiofrequency and depigmenting agents in Fitzpatrick III and IV patients

Historical Background and Scientific Context Scientific interest in metabolic regulatory enzymes expanded rapidly during the late twentieth century as molecular biology techniques improved

Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress

It is an important intracellular antioxidant