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For obese individuals with T2DM a decrease in weight of 510% is clinically significant and is associated with improvements in cardiovascular risk factors ( Statements Author contributions MG and RP have contributed to the conception or design of the work, participated in the drafting of the manuscript and revising it critically for important intellectual content, approved the manuscript for publication and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved

Abstract Gamma-aminobutyric acid (GABA), a ubiquitous non-protein 4-carbon amino acid present in both prokaryotic and eukaryotic organisms

The simultaneous activation of NF-B and Nrf2 creates antagonistic interactions where p65, a subunit of NF-B, suppresses Nrf2 activity to drive the expression of ARE genes, such as HO-1, without p65s own transcriptional activity

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