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In the in vitro tests, the endothelia were perfused for 1 - 3 h with a balanced salt solution containing 250 mg ethylene oxide, 2250 mg 2-chloroethanol, or 5000 mg 1,2-ethanediol/litre

As he points out, this altered glutathione/oxidized glutathione ratio in the substantia nigra suggests that oxidative stress may be a component in the pathogenesis of nigral cell death in PD

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