Food hangs out in your stomach longer, which means you feel full, but also that big, heavy, or high-fat meals, and yes, cocktails, are more likely to result in nausea, reflux, or bloat
Becker, S
Most individuals begin to see initial weight loss within a few weeks, with noticeable results often occurring between four and 12 weeks
In a multicenter, randomized, placebo-controlled dose-finding trial, cagrilintide at doses ranging from 0.3 to 4.5 mg weekly produced dose-dependent weight reductions, with the 4.5 mg dose achieving approximately 10.8% weight loss at 26 weeks compared to 3.0% with placebo

Overall, many had meaningful weight loss, but some individual results varied, according to the Cleveland Clinic: "Those treated for obesity lost an average of 8.4% of body weight before discontinuation and regained an average of 0.5% one year later Those treated for type 2 diabetes lost an average of 4.4% of body weight before discontinuation and lost an additional 1.3% of body weight one year later In the obesity group, 55% gained weight in the year after discontinuation, while 45% kept losing or stayed the same In the diabetes group, 44% gained weight, while 56% kept losing or stayed the same" There were two primary issues that led to patients stopping the medication, which were cost or insurance coverage, and side effects