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Canadian approval typically follows US approval by 1-2 years for obesity medications

They not only aid in achieving these specific weight loss targets but also support the transition to healthier eating patterns and improved metabolic health

Additionally, lipoic acid increased mitochondrial biogenesis through triggering AMP-activated protein kinase (AMPK)-induced transcription factor PGC-1 activation in skeletal muscle of aged mice (48)

The in vivo response represented a greater reduction in ICP than that noted with other drugs commonly used in IIH [18]

Author contributions Dr Lahrouchi and Dr Lodder carried out the whole-exome sequencing analyses, drafted the initial manuscript, reviewed and revised the manuscript, and approved the final manuscript as submitted