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95% CI: 2.33 to 2.86

Overeating is linked to a malfunction in the hypothalamic arcuate nucleus, which is where neuropeptide Y (NPY), agouti-related peptide (AgRP), proopiomelanocortin (POMC), and leptin interact to regulate food intake and body weight

52 Synergistic activation of vagus nerve afferents by both cholecystokinin and leptin mediates their short-term inhibitory effects on food intake

Jobby John PharmD, FACA References: Eli Lilly press release regarding licensing from Chugai Pharmaceuticals, orforglipron as a non-peptide, small-molecule oral GLP-1 agonist

Phytochelatins: the principal heavy-metal complexing peptides of higher plants