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[95] Intramuscular or intravenous injection [edit] Injection of hydroxycobalamin is often used if digestive absorption is impaired, [2] but this course of action may not be necessary with high-dose oral supplements (such as 0.51.0 mg or more), [97] [98] because with large quantities of the vitamin taken orally, even the 1% to 5% of free crystalline B 12 that is absorbed along the entire intestine by passive diffusion may be sufficient to provide a necessary amount

In addition, we observed that HIF-1 protein levels accumulate downstream of mTOR in response to GLP-1R signalling, whereas we also demonstrated that depletion of HIF-1 impaired effects on glycolysis and transcriptional regulation of glycolytic genes

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However, if you're on other medications or have kidney issues, it's best to consult a registered dietitian or healthcare provider