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Pyrogens are endotoxins or exotoxins which induce an immune response

Cycle length 8 to 12 weeks on, 4 to 6 weeks off in common research community protocols

Intestinal barrier dysfunction (leaky gut) permits inappropriate passage of food proteins, microbial components, and environmental toxins into circulation, potentially triggering immune responses that cross-react with body tissues

References PMC The Safety and Efficacy of Growth Hormone Secretagogues GHRH + GHRP synergy