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Functional sepiapterin reductase is a homodimeric enzyme which first converts 6-pyruvoyltetrahydropterin to 1-hydroxy-2-oxopropyltetrahydropterin, which is then reduced to 1-oxo-2-hydroxypropyltetrahydropterin, and then finally to 5,6,7,8-tetrahydrobiopterin, BH 4

An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N -methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder

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