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doi:10.1073/pnas.1733391100

For men, testosterone replacement therapy (TRT) is commonly used to restore hormonal levels, improving energy, muscle mass, and sexual health

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The SELECT trial demonstrated a reduced incidence of cardiovascular outcomes in people with obesity and pre-existing CVD but without T2DM treated once weekly with semaglutide compared with those treated with placebo

Its neuroprotective effects are mediated through multiple pathways, including vascular regeneration, neuroinflammation modulation [125], and regulation of calcium signaling and neurotransmission [126]