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Moreover, the weight loss achieved with GLP-1 RAs combined with lifestyle intervention approaches is comparable to that of surgical intervention, far surpassing the results adolescents can achieve through lifestyle changes alone ( This paper is a narrative review that references the SANRA guidelines for narrative reviews, but was not strictly written according to these guidelines

Patients with Child-Pugh class B or C cirrhosis should not receive ipamorelin until hepatic status is stabilized and the risk-benefit ratio has been reviewed by a hepatologist

Coe and Ross 1990

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But, the synergistic use of both peptides yields optimal results