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and the concentration can be raised to 300uM at pH 9.10
MASLD Substudy Sanyal et al., Nature Medicine (2024) Sanyal and colleagues conducted a prespecified phase 2a substudy of the original phase 2 obesity trial, evaluating retatrutide in participants with metabolic dysfunction-associated steatotic liver disease (MASLD)
Retatrutide achieved up to 24.2% body weight reduction over 48 weeks in the Phase 2 trial published in the New England Journal of Medicine , which involved adults with obesity but without diabetes
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Future research should also integrate genetic and lifestyle factors that may influence vitamin Es effects, allowing for the development of personalized supplementation strategies
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