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Notably, p38 MAPK is highly sensitive to oxidative signals, with low-dose H 2 O 2 sufficient to induce its rapid activation in muscle cells, preceding activation of catabolic regulators like FoxO and NF-B ( Once activated, p38 MAPK and JNK promote transcription of muscle atrophy-related genes

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[DOI] [PMC free article] [PubMed] [Google Scholar] 117.Sadowska A.M., Manuel-Y-Keenoy B., De Backer W.A