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To prevent DFU, patients with diabetes and DPN should inspect their feet daily for injuries, blisters or signs of infection

This energy-intensive process occurs in the mitochondria, where the increased metabolic activity required to produce ATP inherently generates ROS as a byproduct of the ETC (electron transport chain) [84]

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It is important to recognize that hGH therapy is not advisable for those with untreated diabetes, a history of cancer, increased intracranial pressure, existing carpal tunnel syndrome, edema, or critical illness [24]