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(85) found that total body BMD and lumbar spine BMD remained stable in prepubertal PWS children during 9 years of GH therapy, but decreased during adolescence due to incomplete pubertal development, emphasizing the importance of prompt replacement therapy
As a result, these favorable properties enable peptide drugs to secure quicker regulatory approval than small molecule drugs [2]
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Typically, patients who have already been on it previously tend to tolerate side effects better the second time around
