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Furthermore, a recent resting-state functional magnetic resonance imaging (MRI) analysis of 18 women with obesity or polycystic ovary syndrome (PCOS) randomized to either 16-week semaglutide or placebo showed no significant changes in brain regions associated with depression and suicidality 177

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Furthermore, the extensive analysis showed significant reductions in brain natriuretic peptide (BNP), a key, widely recognized blood biomarker of heart failure severity and cardiac distress

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