Lastly, our study focused solely on the risk of psychiatric disorder onset, not on disease progression
Smaller doses tend to lead to fewer side effects, which is why doctors usually start patients on low GLP-1 doses
A combined effect that is bigger than just decreasing calories is thought to be at play when looking at the effects of activating the GLP-1 receptor.[ref] In overweight adults aged 45+, a 4-year-long study using semaglutide for weight loss also prevented HbA1c from rising over time, which was seen in the placebo arm
By starting with or maintaining lower doses, providers hope to balance effectiveness with tolerability
The bottom line At the end of the day, microdosing GLP-1s is just a buzzy way of talking about a different approach to GLP-1s namely, starting (and staying) at the right dose for you, even if its lower than what the manufacturer recommends