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And, as one of the most expressive areas of the face is the upper third, many people seek treatments that can smooth away deeper expression lines that have set in over time

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The E1 gene (symbol: BCKDHB) is located on chromosome 6q14.1 and is composed of 21 exons that generate three alternatively spliced mRNAs that collectively encode a 392 amino acid protein (isoform 1 ) and a 322 amino acid protein (isoform 2)