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Tirzepatide activates both GLP-1 and GIP receptors (dual agonist mechanism), while semaglutide targets only GLP-1

They do not replace resistance training, protein intake, nutrition control, or metabolic care

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Besides, GH acts through its receptor GHR in the liver to activate autophagy, preserve triglycerides, enhance gluconeogenesis, and prevent hypoglycemia in calorie-restricted mice ( in vivo