A randomised controlled trial published in Clinical Infectious Diseases demonstrated that Thymosin Alpha-1 treatment in severe COVID-19 patients reduced 28-day mortality by 30% compared to standard care alone.17 While this was acute disease, not long COVID, it confirms the biological plausibility of the immune mechanism
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miR-9 upregulation leads to inhibition of erythropoiesis by repressing FoxO3
other symptoms that can be treated include behavior and mood alterations (e.g, depression, apathy, anxiety, etc.) which may manifest as decreased facial expression, decreased movement, a state of indifference, and quiet speech
In vitro and in vivo studies also show that downregulation of miR-137 determines an increase in Ca2 + levels and a reduction of A1-40 and A1-42