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Yes GLP-1(Sema) remains the appropriate choice when the research question requires clean GLP-1R isolation without GIP or glucagon receptor co-activation

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To capture the impact of treatment administration methods on quality of life, all analyses were performed with annual disutilities associated with treatment administration ( 0.007 for once-daily oral administration and 0.061 for once-daily injection) applied in the respective treatment arms, sourced from a previously published analysis [44]

At the same time, Somaglutide can also inhibit the decomposition of liver glycogen and gluconeogenesis, reducing the increase in blood sugar