SCFAs, particularly butyrate, have been shown to inhibit NF-B activation by preventing the phosphorylation and degradation of inhibitor proteins (IBs), thereby mitigating inflammatory responses and promoting gut homeostasis (Yao et al., 2024
SURMOUNT-4: maintenance and weight regain The SURMOUNT-4 trial addressed a critical question: what happens when you stop tirzepatide
PIONEER 6 was an event-driven cardiovascular outcome trial (CVOT) that used time from randomization to first occurrence of a major cardiovascular event (MACE) as the primary outcome
Insurance and access challenges The NYU study noted that 50% of lupus patients were initially denied insurance coverage for GLP-1 medications
While direct-to-consumer platforms have increased patient access to GLP-1 RAs, these findings suggest that some do so through impersonal care that prioritizes quick prescriptions over comprehensive care. The majority of the websites included in the study, 39, sold compounded GLP-1s