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10.1016/j.apunsm.2020.08.002 158 OKeefeE

Saturated fatty acids, including animal lipids, solidify when left at room temperature

Zonal organization: Articular cartilage has superficial zone (tangential collagen orientation, highest cell density), middle zone (random collagen orientation, largest proteoglycans), deep zone (perpendicular collagen orientation, calcified interface with bone), and tidemark (boundary between calcified and uncalcified cartilage)

Unlike novel synthetic compounds that require extensive safety testing, GHK-Cu benefits from decades of human exposure data

Neuroimaging studies may show frontotemporal atrophy, progressive supratentorial and infratentorial atrophy, cerebellar atrophy, and periventricular demyelination [101]