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64 Notably, cationic delivery strategies require careful design to support weak, reversible interactions with the cartilage matrix, because an excessively positive charge may favor tight binding, potentially limiting penetrability

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Abstract Angiotensin (Ang) II, the main effector peptide of the reninAng system, increases arterial blood pressure through Ang II type 1A (AT 1a ) receptor-dependent arterial vasoconstriction and by decreasing renal salt and water excretion through extrarenal and intrarenal mechanisms